GENE EXPRESSION WITHIN A HUMAN CHOROIDAL NEOVASCULAR MEMBRANE USING SPATIAL TRANSCRIPTOMICS
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Li-Chun Lin
About
My research interests include the molecular mechanisms of selective vulnerability in neurological disorders. I approach my research questions by studying human postmortem or surgical brain tissues from patients and animal models (pigs, macaques, rodents) for cross-species comparisons.
Work
The University of Iowa
|Core Director
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University of San Francisco
|Postdoctoral Fellow
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University of Pittsburgh
|Predoctoral Researcher
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Publications
Mapping the spatial transcriptomic signature of the hippocampus during memory consolidation
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Spatial transcriptomics reveals unique gene expression changes in different brain regions after sleep deprivation
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NEUROeSTIMator: Using Deep Learning to Quantify Neuronal Activation from Single-Cell and Spatial Transcriptomic Data
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NEUROeSTIMator: Using Deep Learning to Quantify Neuronal Activation from Single-Cell and Spatial Transcriptomic Data
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An 18‐month‐old with white matter calcifications and seizures
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Brain Pathology
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Neuropathology of COVID-19.
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Indian journal of pathology & microbiology
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Tau Pathology Drives Dementia Risk-Associated Gene Networks toward Chronic Inflammatory States and Immunosuppression
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Cell Reports
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Preferential tau aggregation in von Economo neurons and fork cells in frontotemporal lobar degeneration with specific MAPT variants.
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Acta neuropathologica communications
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Von Economo Neurons and Fork Cells: A Neurochemical Signature Linked to Monoaminergic Function.
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Cerebral cortex (New York, N.Y. : 1991)
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Transcriptome changes induced by chronic psychosocial/environmental or neuroendocrine stressors reveal a selective cellular vulnerability of cortical somatostatin (SST) neurons, compared with pyramidal (PYR) neurons.
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Molecular psychiatry
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Somatostatin, neuronal vulnerability and behavioral emotionality.
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Molecular psychiatry
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Reduced brain somatostatin in mood disorders: a common pathophysiological substrate and drug target?
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Frontiers in pharmacology
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A human-mouse conserved sex bias in amygdala gene expression related to circadian clock and energy metabolism.
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Molecular brain
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Sex differences in high-fat diet-induced obesity, metabolic alterations and learning, and synaptic plasticity deficits in mice.
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Obesity (Silver Spring, Md.)
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Treadmill exercise enhances passive avoidance learning in rats: the role of down-regulated serotonin system in the limbic system.
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Neurobiology of learning and memory
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