Li-Chun Lin

About

My research interests include the molecular mechanisms of selective vulnerability in neurological disorders. I approach my research questions by studying human postmortem or surgical brain tissues from patients and animal models (pigs, macaques, rodents) for cross-species comparisons.

Work

The University of Iowa

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Core Director

US

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University of San Francisco

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Postdoctoral Fellow

US

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University of Pittsburgh

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Predoctoral Researcher

US

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Publications

GENE EXPRESSION WITHIN A HUMAN CHOROIDAL NEOVASCULAR MEMBRANE USING SPATIAL TRANSCRIPTOMICS

preprint

Mapping the spatial transcriptomic signature of the hippocampus during memory consolidation

preprint

Spatial transcriptomics reveals unique gene expression changes in different brain regions after sleep deprivation

preprint

An 18‐month‐old with white matter calcifications and seizures

Brain Pathology

journal-article

Neuropathology of COVID-19.

Indian journal of pathology & microbiology

journal-article

NEUROeSTIMator: Using Deep Learning to Quantify Neuronal Activation from Single-Cell and Spatial Transcriptomic Data

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preprint

NEUROeSTIMator: Using Deep Learning to Quantify Neuronal Activation from Single-Cell and Spatial Transcriptomic Data

preprint

Tau Pathology Drives Dementia Risk-Associated Gene Networks toward Chronic Inflammatory States and Immunosuppression

Cell Reports

journal-article

Preferential tau aggregation in von Economo neurons and fork cells in frontotemporal lobar degeneration with specific MAPT variants.

Acta neuropathologica communications

journal-article

Von Economo Neurons and Fork Cells: A Neurochemical Signature Linked to Monoaminergic Function.

Cerebral cortex (New York, N.Y. : 1991)

journal-article

Transcriptome changes induced by chronic psychosocial/environmental or neuroendocrine stressors reveal a selective cellular vulnerability of cortical somatostatin (SST) neurons, compared with pyramidal (PYR) neurons.

Molecular psychiatry

journal-article

Somatostatin, neuronal vulnerability and behavioral emotionality.

Molecular psychiatry

journal-article

Reduced brain somatostatin in mood disorders: a common pathophysiological substrate and drug target?

Frontiers in pharmacology

journal-article

A human-mouse conserved sex bias in amygdala gene expression related to circadian clock and energy metabolism.

Molecular brain

journal-article

Sex differences in high-fat diet-induced obesity, metabolic alterations and learning, and synaptic plasticity deficits in mice.

Obesity (Silver Spring, Md.)

journal-article

Treadmill exercise enhances passive avoidance learning in rats: the role of down-regulated serotonin system in the limbic system.

Neurobiology of learning and memory

journal-article